The actress whose voice was heard regularly on hit show 'The Big Bang Theory' has died. Carol Ann Susi was the voice of Debbie Wolowitz, Mom to lead character Howard Wolowitz.

People Magazine reports that Susi died on Tuesday, after battling an aggressive form of cancer. She was 62 years old.

While Susi's face was never shown on the program, her voice was as famous as any of the lead characters. We all felt sorry for her son when we heard that bellowed "Howard!" The relationship, while bizarre and certainly a bit too close, always seemed to work for them.

The question now is, what will the writers do with the character? Will she die? Or will she move away? Time will tell. At any rate, it's a loss for the show and for the entertainment world.